Two South Park episodes for those of us on the "wrong" side of the Northcross/big-box/Las Manitas debate:
Gnomes (download available from AOL video). The townspeople crusade to save the local coffee shop from an evil "Harbucks." (Here's the episode's Wikipedia entry. Here's a straight-faced deconstruction by a University of Virginia English professor.)
Something Wall-Mart This Way Comes (complete episode). A "Wall-Mart" opens in South Park, wipes out local businesses, and sparks a, uh, "backlash" by the townspeople. (Warning: this one's scatty even for South Park.) Stone and Parker don't reveal their take until the last minute.